New azolyl-derivatives as multitargeting agents against breast cancer and fungal infections: synthesis, biological evaluation and docking study

Nonsteroidal aromatase inhibitors (NSAIs) are well-established drugs for the therapy of breast cancer. However, they display some serious side effects, and their efficacy can be compromised by development chemoresistance. Previously, we have reported different indazole-based carbamates piperidine-sulphonamides as potent inhibitors. Starting from most promising compounds, here synthesised new indazole triazole derivatives evaluated biological activity potential dual agents, targeting both inducible nitric oxide synthase, being this last dysregulated in Furthermore, selected compounds were antiproliferative cytotoxic agents MCF-7 cell line. Moreover, considering therapeutic diversity azole-based all synthesized also antifungals on Candida strains. A docking study, well molecular dynamics simulation, carried out to shed light binding mode interesting compound into target enzymes catalytic sites.